A computer-implemented method, system, and/or computer program product enables automatic toll booth interaction with self-driving vehicles (SDVs). An SDV interrogation transceiver at a toll booth interrogates a driving mode module on an SDV. The SDV is capable of being operated in autonomous mode by an on-board SDV control processor. The driving mode module selectively controls the SDV to be operated in the autonomous mode or in manual mode, in which a human driver of the SDV manually operates the SDV. The SDV interrogation transceiver receives a driving mode descriptor of the SDV, which identifies whether the SDV currently is operating in the autonomous mode or in the manual mode while traveling on a toll road. An adjusted toll charge for the SDV to travel on the toll road is then transmitted based on the driving mode descriptor.