Invention Grant
- Patent Title: OX40L fusion proteins and uses thereof
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Application No.: US14722679Application Date: 2015-05-27
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Publication No.: US09718870B2Publication Date: 2017-08-01
- Inventor: Melissa Damschroder , Michael Oberst , Scott Hammond , Hui Feng
- Applicant: MEDIMMUNE, LLC
- Applicant Address: US MD Gaithersburg
- Assignee: MedImmune, LLC
- Current Assignee: MedImmune, LLC
- Current Assignee Address: US MD Gaithersburg
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/385 ; C07K16/00 ; C12P21/08 ; C07H21/04 ; C12P21/06 ; C12N15/00 ; C12N5/00 ; C07K14/705 ; A61K39/39
Abstract:
The disclosure provides OX40L huIgG4 fusion polypeptide subunits comprising a human IgG4 Fc domain, a trimerization domain, and the receptor binding domain of Ox40 ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.
Public/Granted literature
- US20160024176A1 OX40L FUSION PROTEINS AND USES THEREOF Public/Granted day:2016-01-28
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