An item can be authenticated based on a first, second, third, and fourth identifier, wherein the identifiers are incorporated into various parts of product packaging. In some embodiments, the first, second, and fourth identifiers can be a QR code, a bar code, a serial number, any RFID tag, or a combination thereof, and the third identifier can be an image type, for example, a type of animal, and image location, for example, a quadrant. The identifiers can be scanned or inputted manually by a user. When the four identifiers are authenticated, the product is deemed to be authentic, whereas when the four identifiers are not authenticated, the product is deemed to be counterfeit. In some implementations, a user can authenticate the items using a smart phone, smart phone app, tablet, tablet app, website, web-based application, and/or the like.