Invention Grant
- Patent Title: Methods of measuring levels of phosphorylated neuronal nitric oxide synthase
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Application No.: US14408393Application Date: 2012-12-07
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Publication No.: US09696309B2Publication Date: 2017-07-04
- Inventor: Irina Burd , Talaibek Borbiev , Elisabeth Nigrini , Michael Johnston
- Applicant: THE JOHNS HOPKINS UNIVERSITY , KENNEDY KRIEGER INSTITUTE, INC.
- Applicant Address: US MD Baltimore US MD Baltimore
- Assignee: The Johns Hopkins University,Kennedy Krieger Institute, Inc.
- Current Assignee: The Johns Hopkins University,Kennedy Krieger Institute, Inc.
- Current Assignee Address: US MD Baltimore US MD Baltimore
- Agency: Johns Hopkins Technology Ventures
- International Application: PCT/US2012/068425 WO 20121207
- International Announcement: WO2013/086306 WO 20130613
- Main IPC: G01N33/535
- IPC: G01N33/535 ; G01N33/573 ; G01N33/68
Abstract:
The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. In a specific embodiment, a method for diagnosing perinatal brain injury in a patient comprises the steps of (a) determining the ratio of phosphorylated nNOS to unphosphorylated nNOS in a sample collected from the patient using an ELISA; and (b) comparing the ratio with predefined ratios of the same proteins that correlate to a patient having perinatal brain injury and predefined ratios of the same proteins that correlate to a patient not having perinatal brain injury, wherein a correlation to one of the predefined ratios provides the diagnosis.
Public/Granted literature
- US20150247854A1 BIOMARKERS FOR BRAIN INJURY Public/Granted day:2015-09-03
Information query
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