A fastening bolt includes a shaft defining a central axis, a head, a drilling portion, and first threads alternating with second threads. The first threads and the second threads have different outer diameters. Each first thread has a trailing surface facing the head and inclined to a line perpendicular to the central axis by a trailing angle and a leading surface facing the drilling portion and inclined to the line by a leading angle. The trailing angle is smaller than the leading angle to build an asymmetrical form. Some threads near the drilling portion form respective cutting grooves and recesses thereon. Each cutting groove is formed by walls with different lengths and opened at an angle which does not exceed 90 degrees. The bolt breaks the workpiece quickly by the cutting grooves and recesses. The asymmetrical first threads help enter the workpiece quickly and attain a firm engagement therewith.