- Patent Title: Reactions of thiadiazolyl-oximinoacetic acid derivative compounds
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Application No.: US15319104Application Date: 2015-06-19
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Publication No.: US09695196B2Publication Date: 2017-07-04
- Inventor: Kristos Adrian Moshos , Valdas Jurkauskas , Manuel Scanu , Michele Benotti
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent J. Eric Thies; John C. Todaro
- International Application: PCT/US2015/036704 WO 20150619
- International Announcement: WO2015/196077 WO 20151223
- Main IPC: C07D501/04
- IPC: C07D501/04 ; C07D285/08
Abstract:
This disclosure relates to an improved synthesis of cephalosporin antibiotic compounds such as ceftolozane, and compositions and methods of use thereof. Thiadiazolyl-oximinoacetic acid compounds such as TATD can be reacted to yield the activated thiadiazolyl-oximinoacetic acid methanesulfonate ester compounds useful in the manufacture of cephalosporin antibiotic compounds.
Public/Granted literature
- US20170129906A1 REACTIONS OF THIADIAZOLYL-OXIMINOACETIC ACID DERIVATIVE COMPOUNDS Public/Granted day:2017-05-11
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