Invention Grant
- Patent Title: Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents
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Application No.: US15100818Application Date: 2014-12-08
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Publication No.: US09695113B2Publication Date: 2017-07-04
- Inventor: Torfinn Haaland , Arne Askildsen , Rita Heskestad Kalleberg , Sumihar Silalahi , Alf Martin Farbrot , Inger Dagny Saanum
- Applicant: GE Healthcare AS
- Applicant Address: NO Oslo
- Assignee: GE Healthcare AS
- Current Assignee: GE Healthcare AS
- Current Assignee Address: NO Oslo
- Agency: Wood IP LLC
- International Application: PCT/EP2014/076873 WO 20141208
- International Announcement: WO2015/082718 WO 20150611
- Main IPC: C07C231/24
- IPC: C07C231/24 ; C07C231/02 ; C07C237/46
Abstract:
Alternative continuous downstream processes for the production of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”) are described. Compound A is a key intermediate in the production of iodixanol and iohexol, which are two of the biggest commercially available non-ionic x-ray contrast media agents.
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