Embodiments of a system and method for selecting a duplex mode for a service operating in a Wireless Network are generally described herein. In some embodiments, a mobile device may receive one or more traffic packets related to an establishment or a re-establishment of a service at the mobile device, and may select a duplex mode for the service. In some embodiments, the mobile device may be an IEEE 802.11 Station (STA). The mobile device may be configured to select full-duplex as the duplex mode when a delay requirement associated with the service is less than a predetermined delay threshold and when a calibration overhead associated with the mobile device or the service is less than a predetermined calibration overhead threshold. In addition, the mobile device may also be configured to select time-division duplex (TDD) or frequency-division duplex (FDD) as the duplex mode when the delay requirement is less than the delay threshold and when the calibration overhead is less than the calibration overhead threshold.