Invention Grant
- Patent Title: In vitro method using hetero-oligomeric T1R1/T1R3 taste receptors to identify umami tastants
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Application No.: US14860047Application Date: 2015-09-21
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Publication No.: US09671390B2Publication Date: 2017-06-06
- Inventor: Mark Zoller , Xiaodong Li , Lena Staszewski , Shawn O'Connell , Sergey Zozulya , Jon Elliot Alder , Hong Xu , Fernando Echeverri
- Applicant: SENOMYX, INC.
- Applicant Address: US CA San Diego
- Assignee: SENOMYX, INC.
- Current Assignee: SENOMYX, INC.
- Current Assignee Address: US CA San Diego
- Agency: LeClairRyan, A Professional Corporation
- Agent Robin L. Teskin
- Main IPC: G01N33/50
- IPC: G01N33/50 ; C07K14/705 ; G01N33/566 ; C12Q1/68
Abstract:
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.
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