Invention Grant
- Patent Title: Amorphous allisartan isoproxil, preparation method therefor, and pharmaceutical composition containing amorphous allisartan isoproxil
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Application No.: US15032532Application Date: 2014-10-29
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Publication No.: US09670184B2Publication Date: 2017-06-06
- Inventor: Duanming Tan , Jun Ou , Guanhao Ye , Shui Bu
- Applicant: SHENZHEN SALUBRIS PHARMACEUTICALS CO. LTD
- Applicant Address: CN Shenzhen
- Assignee: SHENZHEN SALUBRIS PHARMACEUTICALS CO. LTD
- Current Assignee: SHENZHEN SALUBRIS PHARMACEUTICALS CO. LTD
- Current Assignee Address: CN Shenzhen
- Agency: Leason Ellis LLP
- Priority: CN201310535073 20131101
- International Application: PCT/CN2014/089775 WO 20141029
- International Announcement: WO2015/062498 WO 20150507
- Main IPC: C07D403/10
- IPC: C07D403/10 ; A61K31/4178

Abstract:
The present invention relates to an amorphous allisartan isoproxil which is an angiotensin II receptor blocker with good flowability and a large bulk density and with no obvious electrostatic phenomenon; the find of the amorphous allisartan isoproxil can effectively reduce the generation of dust pollution during the production, thereby providing convenience the production of allisartan isoproxil. The present invention also relates to a pharmaceutical composition containing the amorphous allisartan isoproxil. The pharmaceutical composition is highly stable, and allisartan isoproxil formulation prepared from the pharmaceutical composition can effectively ensure the quality of the drug.
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