A semiconductor device includes a first circuit block that is connected between a first power supply voltage line and a first reference voltage line, a second circuit block that is connected between a second power supply voltage line and a second reference voltage line and transmits and receives signals with the first circuit block, a first clamp circuit that clamps a potential difference between the second power supply voltage line and the first reference voltage line, a resistor circuit that is connected between the second power supply voltage line and the second circuit block and includes a resistance value that is greater than an impedance of the first clamp circuit, and a second clamp circuit that clamps a potential difference between a line connected between the resistor circuit and the second circuit block and the first reference voltage line.