In accordance with an embodiment of the present invention, a noise/interference reduction method for speech enhancement processing includes selecting one of the microphones as a main microphone wherein the signal from the main microphone is used as a target signal, the selection of the main microphone is adaptive for mono output case, and the selection of the main microphone is fixed for stereo output case. The noise/interference component signal is estimated by subtracting voice component signal from a first microphone input signal wherein the voice component signal is evaluated as a first replica signal produced by passing a second microphone input signal through a first adaptive filter. A noise/interference reduced signal is output by subtracting a second replica signal from the target signal, wherein the second replica signal is produced by passing the estimated noise/interference component signal through a second adaptive filter.