A method may include standardizing an input image to produce a standardized input image; structurizing the standardized input image to be characterized by a plurality of anatomical properties; mapping the input image to one or more reference cases of a plurality of reference cases using the plurality of anatomical properties, wherein the one or more reference cases are associated with first non-image clinical information; and determining second non-image clinical information for the input image based on the one or more reference cases and the first non-image clinical information.