Systems and methods are provided that receive a clinical identifier, an acquisition condition target, and one or more patient characteristics. The systems and methods further generate a scan attribute based on the clinical identifier. The scan attribute corresponding to characteristics of a resultant medical image. The systems and methods determine select scan settings from a plurality of scan settings based on the scan attribute and the one or more patient characteristics, and calculate candidate acquisition conditions associated with the select scan settings. Further, the systems and methods identify one of the select scan settings as a scan prescription based on a relation between the candidate acquisition conditions and the acquisition condition target.