A musical instrument mute, a mute body, a microphone, a speaker, and a microcontroller for electronic modification of sound emitted from a musical instrument. A mute body is positionable within a bell or horn of the musical instrument, and the body has a proximal end portion and is configured to at least partially occlude the bell or horn. A microphone is positioned at the proximal end portion of the mute body and is configured to transduce a sound produced by the musical instrument. A speaker is positioned in the mute body as well. A microcontroller is configured to receive a signal from the microphone and to electronically modify the sound of the instrument when emitted through the speaker. Some mutes also provide a communication transceiver, sensors, and input devices to control and manipulate sound produced by the mute.