Invention Grant
- Patent Title: Compounds and methods for detection of enzymes that remove formyl, succinyl, methyl succinyl or myristoyl groups from ε-amino lysine moieties
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Application No.: US12930693Application Date: 2011-01-13
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Publication No.: US09637773B2Publication Date: 2017-05-02
- Inventor: Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
- Applicant: Konrad T. Howitz , Zhongda Zhang , Anne Kisielewski , Elizabeth Dale , Wayne Forrest Patton
- Applicant Address: US NY Farmingdale
- Assignee: Enzo Life Sciences, Inc.
- Current Assignee: Enzo Life Sciences, Inc.
- Current Assignee Address: US NY Farmingdale
- Agent Paul Diamond, Esq.
- Main IPC: C07D407/00
- IPC: C07D407/00 ; C07D493/00 ; C07D319/00 ; C07D323/00 ; C07D305/14 ; C07D307/94 ; C07D311/96 ; C07D313/06 ; C07D313/20 ; C07D317/72 ; C07D311/02 ; C12Q1/34 ; C07D311/16 ; C07D493/10
Abstract:
Provided is a compound that comprises the structure: where SIG is a signaling molecule and R3 is a formyl, a succinyl, a methyl succinyl, or a myristoyl. Also provided is a kit is provided that comprises the above compound, with instructions for determining the presence of the enzyme. Additionally, a method is provided for determining whether a sample has an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine. Also provided is a method of determining whether a molecule inhibits an enzyme that removes a succinyl, a methyl succinyl, a formyl, or a myristoyl moiety from an ε-amino of a lysine.
Public/Granted literature
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