Invention Grant
- Patent Title: Selective cartilage therapy
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Application No.: US14409312Application Date: 2013-06-25
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Publication No.: US09637531B2Publication Date: 2017-05-02
- Inventor: Richard T. Lee , Parth Patwari , Francesco Loffredo , James Pancoast , Zheng Xin Dong , Todd Vannelli
- Applicant: The Brigham and Women's Hospital, Inc.
- Applicant Address: US MA Boston
- Assignee: The Brigham and Women's Hospital, Inc
- Current Assignee: The Brigham and Women's Hospital, Inc
- Current Assignee Address: US MA Boston
- Agency: Brown Rudnick LLP
- Agent Thomas C. Meyers
- International Application: PCT/US2013/047556 WO 20130625
- International Announcement: WO2014/004467 WO 20140103
- Main IPC: C07K14/65
- IPC: C07K14/65 ; C07K7/00 ; C07K14/475 ; A61K38/30 ; C07K14/47
Abstract:
The present invention relates to compositions, methods and kits for delivery of an IGF-1 protein or a functional fragment or variant, derivative thereof to cells or tissues that express proteoglycans. More specifically, the present invention relates to fusion proteins comprising a heparin binding protein (HB) comprising SEQ ID NO: 1 or SEQ ID NO: 2. Other aspects relate to use of a HB-IGF-1 fusion proteins in methods to deliver IGF-1 to the cartilage for the treatment of a cartilage related disease and disorder in a subject.
Public/Granted literature
- US20150166628A1 SELECTIVE CARTILAGE THERAPY Public/Granted day:2015-06-18
Information query
