An interface switching control method, a portable terminal and a portable mobile device using the method are disclosed. The method is applied in a portable terminal including a first device and a second device. The first device is connected to a shared device via a first interface, and the second device is connected to the shared device via a second interface. The portable terminal has a first state in which the first device and the second device are connected, and a second state in which the first device and the second device are disconnected. The method includes detecting a state of the portable terminal; and when the detection result indicates that the portable terminal is in the first state, controlling the first interface to be in an enabled state and controlling the second interface to be in a disabled state. The method achieves a real-time switching control over the interfaces for the shard device, and optimizes the interface control for the hybrid-system portable terminal. It is possible to meet various system performance requirements of different devices and reduce the system power consumption by enabling the interfaces required by the respective devices according to the different state of the portable terminal.