An apparatus comprises at least one processing platform implemented using at least one processing device comprising a processor coupled to a memory. The processing platform comprises virtualization infrastructure, an assurance layer and an analytic layer. The assurance and analytic layers are configured to provide data collection and event management functionality to support automation relating to resources of the virtualization infrastructure and associated workloads. By way of example, the assurance and analytic layers illustratively comprise respective deterministic and indeterministic functional groupings of components. The functional groupings of components of the assurance and analytic layers are utilized to implement closed-loop remediation workflows and other types of automation relating to the virtualization infrastructure resources and their associated workloads.