A self-powered processing device comprises both a processing device and a power generator that are physically, electrically, and thermally coupled to one another. The power generator can be a fuel cell that can be manufactured from materials that can also support processing circuitry, such as silicon-based materials. A thermal coupling between the power generator and the processing device can include a thermoelectric either generating electrical power from the temperature differential or consuming electrical power to generate a temperature differential. A computing device with self-powered processing devices also includes energy storage devices to store excess energy produced by the self-powered processing device and provide it back during times of need. The self-powered processing device comprises either a wireless or wired network connection, the latter being connectable to a slot on a backplane that can aggregate multiple self-powered processing devices and provide fuel delivery paths for them.