An Enterprise Resource Planning (ERP) gateway is provided for routing of ERP messages to Manufacturing Execution System (MES) applications. The gateway can receive a message from an ERP system via a manufacturing services bus specifying a business objective requiring action at a control level of an enterprise. The received message can be routed to a selected MES application capable of carrying out the business objective based on attributes within the message. Message routing can be based on location tags contained in the message. The message can also be routed to a selected subset of MES applications based on an analysis of respective capabilities and control contexts of the MES applications. Messages can be routed between the ERP system and the MES applications via the manufacturing services bus, which can manage protocol transformations for a heterogeneous set of applications.