Invention Grant
- Patent Title: Histidyl-tRNA synthetase-Fc conjugates
- Patent Title (中): 组氨酰-tRNA合成酶-Fc偶联物
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Application No.: US14214491Application Date: 2014-03-14
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Publication No.: US09587235B2Publication Date: 2017-03-07
- Inventor: Ying Buechler , Kyle Chiang , Minh-Ha Do , Darin Lee , Kristi Piehl , Marc Thomas , Jeffry D. Watkins , Chi-Fang Wu , John D. Mendlein
- Applicant: aTyr Pharma Inc.
- Applicant Address: US CA San Diego
- Assignee: aTyr Pharma, Inc.
- Current Assignee: aTyr Pharma, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Cooley LLP
- Main IPC: C12N9/96
- IPC: C12N9/96 ; C12N9/00
Abstract:
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.
Public/Granted literature
- US20140349369A1 HISTIDYL-TRNA SYNTHETASE-FC CONJUGATES Public/Granted day:2014-11-27
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