Invention Grant
US09587022B2 Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity
有权
具有改善的HIV-1中和活性的糖改性抗CD4抗体
- Patent Title: Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity
- Patent Title (中): 具有改善的HIV-1中和活性的糖改性抗CD4抗体
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Application No.: US14133256Application Date: 2013-12-18
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Publication No.: US09587022B2Publication Date: 2017-03-07
- Inventor: Ruijiang Song , David D. Ho
- Applicant: THE ROCKEFELLER UNIVERSITY
- Applicant Address: US NY New York
- Assignee: THE ROCKEFELLER UNIVERSITY
- Current Assignee: THE ROCKEFELLER UNIVERSITY
- Current Assignee Address: US NY New York
- Agency: Clark & Elbing LLP
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
Disclosed herein are glycan-modified anti-CD4 monoclonal antibodies with N-linked glycans attached to the variable region. Expression vectors and cell lines useful for the production of such antibodies, and use of such antibodies for HIV prevention and therapy are also disclosed.
Public/Granted literature
- US20140248295A1 GLYCAN-MODIFIED ANTI-CD4 ANTIBODIES FOR HIV PREVENTION AND THERAPY Public/Granted day:2014-09-04
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