Invention Grant
- Patent Title: Monoclonal antibodies capable of reacting with a plurality of influenza virus A subtypes
- Patent Title (中): 能够与多种流感病毒A亚型反应的单克隆抗体
-
Application No.: US14938101Application Date: 2015-11-11
-
Publication No.: US09587011B2Publication Date: 2017-03-07
- Inventor: Roberto Burioni , Massimo Clementi
- Applicant: Pomona Ricerca S.r.l.
- Applicant Address: IT Turin
- Assignee: Pomona Ricerca S.r.l.
- Current Assignee: Pomona Ricerca S.r.l.
- Current Assignee Address: IT Turin
- Agency: MacMillan, Sobanski & Todd, LLC
- Priority: ITTO2008A0204 20080317
- Main IPC: C12N15/74
- IPC: C12N15/74 ; C07K16/10 ; A61K47/48 ; C07K16/42 ; G01N33/68
Abstract:
Monoclonal antibodies directed against the influenza A virus are described, which have the advantageous and unpredicted property of being able to bind a plurality of subtypes of the influenza A virus. One preferred embodiment is the antibody designated as Fab28, which displays a neutralizing activity against a plurality of subtypes of the influenza A virus. Anti-idiotype antibodies directed against the monoclonal antibodies of the invention, immunogenic or vaccine compositions comprising the monoclonal antibodies of the invention are also described, as well as therapeutic, prophylactic and diagnostic applications for the monoclonal antibodies of the invention. The monoclonal antibodies of the invention can also be used for testing antibody preparations to be used as vaccines.
Public/Granted literature
- US20160060325A1 Monoclonal Antibodies Capable of Reacting with a Plurality of Influenza Virus a Subtypes Public/Granted day:2016-03-03
Information query
IPC分类:
