Methods are provided for administering compositions for topical dermatological treatment and resolution of skin cancer lesions in humans and domestic animals, including especially light skinned individuals of equine, bovine, porcine, canine and other species susceptible to developing skin cancer. The compositions used to treat and resolve the skin cancer lesions generally comprise complexation of peptone digests of various proteins with copper(II) salts, indium(III) salts, tin(II) salts, and tin(IV) salts. These compositions adhere tightly to the lesion surface, strongly resist enzymatic breakdown by the cancerous tissue, and possess very strong tissue remodeling actions.