Invention Grant
US09586960B2 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de] quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid salt crystal forms
有权
4 - （（6bR，10aS）-3-甲基-2,3,6b，9,10,10a-六氢-1H-吡啶并[3'，4'：4,5]吡咯并[1,2,3-de ]喹喔啉-8（7H） - 基）-1-（4-氟苯基）-1-丁酮甲苯磺酸盐晶体形式
![4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de] quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid salt crystal forms](/docs/US/2017-03-07/US09586960B2/abs.jpg.600x600.jpg)
- Patent Title: 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de] quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid salt crystal forms
- Patent Title (中): 4 - （（6bR，10aS）-3-甲基-2,3,6b，9,10,10a-六氢-1H-吡啶并[3'，4'：4,5]吡咯并[1,2,3-de ]喹喔啉-8（7H） - 基）-1-（4-氟苯基）-1-丁酮甲苯磺酸盐晶体形式
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Application No.: US14954845Application Date: 2015-11-30
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Publication No.: US09586960B2Publication Date: 2017-03-07
- Inventor: John Tomesch , Lawrence P. Wennogle
- Applicant: John Tomesch , Lawrence P. Wennogle
- Applicant Address: US NY New York
- Assignee: INTRA-CELLULAR THERAPIES, INC.
- Current Assignee: INTRA-CELLULAR THERAPIES, INC.
- Current Assignee Address: US NY New York
- Agency: Hoxie & Associates LLC
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D471/22 ; C07D471/16 ; C07C309/30
![4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de] quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone toluenesulfonic acid salt crystal forms](/abs-image/US/2017/03/07/US09586960B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to toluenesulfonic acid addition salt crystals of 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′: 4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-fluorophenyl)-1-butanone, and methods of using such crystals as 5-hydroxytryptamine 2 receptor agonists and antagonists in treating disorders of the central nervous system.
Public/Granted literature
- US20160194325A1 SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SOLID Public/Granted day:2016-07-07
Information query
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