Invention Grant
US09585933B2 Therapeutic use of peptide inhibitors of NADPH oxidase; aerosolization as a delivery mechanism
有权
NADPH氧化酶肽抑制剂的治疗用途; 雾化作为输送机制
- Patent Title: Therapeutic use of peptide inhibitors of NADPH oxidase; aerosolization as a delivery mechanism
- Patent Title (中): NADPH氧化酶肽抑制剂的治疗用途; 雾化作为输送机制
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Application No.: US14608655Application Date: 2015-01-29
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Publication No.: US09585933B2Publication Date: 2017-03-07
- Inventor: Patrick J. Pagano
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pennsylvania—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pennsylvania—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: The Webb Law Firm
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/08 ; A61P9/00 ; A61P11/00
Abstract:
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2. Conditions treatable in this manner include, without limitation, one or more of: right ventricular hypertrophy; pulmonary hypertension; acute lung injury; obstructive sleep apnea; ischemia/reperfusion injury in the lung; pulmonary fibrosis; an obstructive lung disorder such as Chronic Obstructive Pulmonary Disease (COPD), asthma, cystic fibrosis and emphysema; and atherosclerosis.
Public/Granted literature
- US20150297670A1 "Therapeutic Use of Peptide Inhibitors of NADPH Oxidase; Aerosolization as a Delivery Mechanism" Public/Granted day:2015-10-22
Information query
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