Invention Grant
US09585881B2 Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
有权
取代的吡咯烷作为治疗血栓栓塞性疾病的因子XIa抑制剂
- Patent Title: Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases
- Patent Title (中): 取代的吡咯烷作为治疗血栓栓塞性疾病的因子XIa抑制剂
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Application No.: US15180382Application Date: 2016-06-13
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Publication No.: US09585881B2Publication Date: 2017-03-07
- Inventor: Akira Imagawa , Takashi Kondo , Taihei Nishiyama , Steve Courtney , Chris Yarnold , Osamu Ichihara , Stuart Flanagan
- Applicant: ONO PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Osaka
- Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: GB1209138.5 20120524
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D401/14 ; C07D413/14 ; C07D401/04 ; C07D403/04 ; C07D403/14 ; C07D413/04 ; C07D207/50 ; C07D401/06 ; C07D403/10
Abstract:
The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.
Public/Granted literature
- US20160287582A1 SUBSTITUTED PYRROLIDINES AS FACTOR XIA INHIBITORS FOR THE TREATMENT THROMBOEMBOLIC DISEASES Public/Granted day:2016-10-06
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