A framework for origin-destination (OD) analysis of vehicle trajectory data is described herein. In accordance with one aspect, a vehicle trajectory dataset is provided to an OD analyzer. The vehicle trajectory dataset includes vehicle trajectory data collected from a sensor network having a plurality of sensor stations for detecting vehicles. The sensor stations of the sensor network are distributed in a geographical area of interest, where the vehicle trajectory data include trajectories of vehicles captured by the sensor network. The vehicle trajectory dataset may be analyzed by the OD analyzer to determine an origin and a destination of trips for trajectories of the vehicles in the vehicle trajectory dataset. The analysis includes calculating a probability distribution of travel time between sensor pairs of the sensor network of a number of (dropped-out) intermediate stations, and determining a stop probability between a station pair in the trajectories of the vehicles, where a stop is a destination of a previous trip and an origin of a next trip in the trajectories.