Invention Grant
US09562907B2 Aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method
有权
基于没有靶固定的石墨烯的适体筛选方法和从该方法获得的适体
- Patent Title: Aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method
- Patent Title (中): 基于没有靶固定的石墨烯的适体筛选方法和从该方法获得的适体
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Application No.: US15066514Application Date: 2016-03-10
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Publication No.: US09562907B2Publication Date: 2017-02-07
- Inventor: Man Bock Gu , Jee Woong Park , Tatavarty Rameshwar
- Applicant: Korea University Research and Business Foundation
- Applicant Address: KR Seoul
- Assignee: Korea University Research and Business Foundation
- Current Assignee: Korea University Research and Business Foundation
- Current Assignee Address: KR Seoul
- Agency: Fox Rothschild LLP
- Priority: KR10-2011-0088066 20110831; KR10-2012-0043230 20120425
- Main IPC: C07H21/04
- IPC: C07H21/04 ; G01N33/574 ; C12N15/115 ; C12N7/00 ; B01D15/38 ; C12N9/10 ; G01N33/53 ; C12N15/10 ; C12Q1/68 ; G01N33/569 ; G01N33/68
Abstract:
Provided is aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method, and more particularly, a new GO-SELEX method without target immobilization in which a single-stranded nucleic acid pool may react with a non-bound target material or a counter-target material, after which a single-stranded nucleic acid which has not been bound to the target or counter-target may be separated by using the graphene. Also, the specific aptamer obtained through the above-described method may be used for diagnosing target related diseases.
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