Invention Grant
- Patent Title: Anti-ROBO4 antibody
- Patent Title (中): 抗ROBO4抗体
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Application No.: US14966292Application Date: 2015-12-11
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Publication No.: US09562096B2Publication Date: 2017-02-07
- Inventor: Yoshitaka Isumi , Toshiyuki Sato , Jun Hasegawa , Tatsuya Inoue
- Applicant: DAIICHI SANKYO COMPANY, LIMITED
- Applicant Address: JP Tokyo
- Assignee: DAIICHI SANKYO COMPANY, LIMITED
- Current Assignee: DAIICHI SANKYO COMPANY, LIMITED
- Current Assignee Address: JP Tokyo
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: JP2012-103929 20120427; JP2013-011042 20130124
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/395 ; C07K16/28 ; A61K39/00
Abstract:
Problem to be SolvedThe present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.
Public/Granted literature
- US20160108120A1 ANTI-ROBO4 ANTIBODY Public/Granted day:2016-04-21
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