Invention Grant
- Patent Title: Vortioxetine salt and crystal thereof, their preparation method, pharmaceutical compositions and usage
- Patent Title (中): 伏妥西汀盐及其结晶，其制备方法，药物组合物和用途
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Application No.: US15048868Application Date: 2016-02-19
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Publication No.: US09562024B2Publication Date: 2017-02-07
- Inventor: Xiaoye Song , Xiaoxia Sheng , Xiaohong Sheng
- Applicant: HANGZHOU PUSHAI PHARMACEUTICAL TECHNOLOGY CO., LTD
- Applicant Address: CN Hangzhou
- Assignee: HANGZHOU PUSHAI PHARMACEUTICAL TECHNOLOGY CO., LTD
- Current Assignee: HANGZHOU PUSHAI PHARMACEUTICAL TECHNOLOGY CO., LTD
- Current Assignee Address: CN Hangzhou
- Agency: Duane Morris LLP
- Priority: CN201310415148 20130912
- Main IPC: C07D295/096
- IPC: C07D295/096
Abstract:
The present invention relates to the novel vortioxetine salts, solvates and crystalline forms thereof, specifically, vortioxetine hemihydrobromide and a crystalline form thereof, and isopropanol solvate of vortioxetine hydrobromide and a crystalline form thereof. Compared to the known vortioxetine hydrobromide, the vortioxetine salts, solvates and crystalline forms of the present invention have improved features in stability, hygroscopicity and purity. The present invention also relates to preparation methods of the vortioxetine salts, solvates and crystalline forms, pharmaceutical compositions thereof and their uses in the manufacture of antidepressant drugs.
Public/Granted literature
- US20160214950A1 VORTIOXETINE SALT AND CRYSTAL THEREOF, THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USAGE Public/Granted day:2016-07-28
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