Systems, methods, and apparatuses are disclosed for providing a high speed adaptive thermal printhead interface. In one embodiment, an apparatus is provided comprising at least one processor; and at least one memory including computer program instructions, the computer program instructions being configured to, when executed by the at least one processor, cause the apparatus at least to determine identifier information for a connected printhead; retrieve printhead interface configuration data for a configurable printhead interface based at least in part on the identifier information; configure printhead interface circuitry in accordance with the printhead interface configuration data; and enable communication with the printhead through the configurable printhead interface.