Disclosed embodiments include an end-to-end UE and eNB HARQ protocol design for various TDD-FDD joint operation wireless network configurations. Designs for timing of HARQ feedback in response to PDSCH and PUSCH transmissions (or simply, PDSCH and PUSCH) include both HARQ feedback from a UE, and HARQ feedback from an eNB. The PUSCH HARQ timeline embodiments also include both self-scheduling and cross-carrier scheduling scenarios for PUSCH transmissions. In addition, designs for the cross-carrier scheduling scenarios contemplate an FDD scheduling cell or a TDD scheduling cell.