A system and method for estimating a location of a wireless device receiving signals from plural nodes of a communications network. A wireless device may be directed to transmit a first signal having one or more predetermined parameters. At one or more location measurement units (“LMU”) an uplink time of arrival (“TOA”) measurement between the wireless device and one or more of the plural nodes or LMUs may be determined as a function of the first signal transmitted from the wireless device. Downlink signal measurements of signals received by the wireless device may be collected, and a location of the wireless device determined as a function of the uplink TOA measurements and the collected downlink signal measurements.