In accordance with embodiments of the present disclosure, an information handling system may include a processor, a first information handling resource communicatively coupled to the processor, and a second information handling resource communicatively coupled to the processor and the first information handling resource. The first information handling resource and the second information handling resource may be configured to, in concert determine an optimum delay between opposite polarity signals for differential signals communicated from the first information handling resource to the second information handling resource via a path comprising a differential pair and transmit data from the first information handling resource to the second information handling resource via the path by inserting a delay into one of the opposite polarity signals equal to the optimum delay.