Each computing node of a distributed computing system may implement a hardware mechanism at the network interface for message driven prefetching of application data. For example, a parallel data-intensive application that employs function shipping may distribute respective portions of a large data set to main memory on multiple computing nodes. The application may send messages to one of the computing nodes referencing data that is stored locally on the node. For each received message, the network interface on the recipient node may extract the reference, initiate the prefetching of referenced data into a local cache (e.g., an LLC), and then store the message for subsequent interpretation and processing by a local processor core. When the processor core retrieves a stored message for processing, the referenced data may already be in the LLC, avoiding a CPU stall while retrieving it from memory. The hardware mechanism may be configured via software.