The invention discloses a method for preparing leather for cases, which comprises: a. selecting cow leather, which comprises dermis layer and subcutaneous tissue layer; b. uniformly cutting the subcutaneous tissue layer as an lamellar layer, and holding it in the inner side of the cow leather; c. sculpturing the cut lamellar subcutaneous tissue layer as a desired embossed pattern, and removing its peripheral portion; d. placing the cow leather sculptured with embossed pattern in a three-dimensional mold, and pressing the embossed pattern portion towards the inner side of the dermis layer so that the raised pattern structure same with the embossed pattern is formed on the outer surface of the dermis layer; e. performing antiseptic treatment; f. performing rubber injection treatment; g. inlaying metal trim parts. With the above processing, the present invention can produce leather for cases with aesthetic style, good visual effect and noticeable feeling of touch.