Invention Grant
US09534253B2 Base-by-base ratcheting of DNA/RNA in a Y-shaped nanochannel
有权
在Y形纳米通道中DNA / RNA的逐个碱基加工
- Patent Title: Base-by-base ratcheting of DNA/RNA in a Y-shaped nanochannel
- Patent Title (中): 在Y形纳米通道中DNA / RNA的逐个碱基加工
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Application No.: US14615891Application Date: 2015-02-06
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Publication No.: US09534253B2Publication Date: 2017-01-03
- Inventor: Binquan Luan , Ruhong Zhou
- Applicant: International Business Machines Corporation
- Applicant Address: US NY Armonk
- Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
- Current Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
- Current Assignee Address: US NY Armonk
- Agency: Cantor Colburn LLP
- Agent Vazken Alexanian
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N27/447 ; G01N27/453 ; B82Y30/00 ; B82Y5/00

Abstract:
A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.
Public/Granted literature
- US20150153309A1 BASE-BY-BASE RATCHETING OF DNA/RNA IN A Y-SHAPED NANOCHANNEL Public/Granted day:2015-06-04
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