Invention Grant
US09533973B2 Allosteric modulators of 5-hydroxytryptamine 2C receptor (5-HT2CR)
有权
5-羟色胺2C受体（5-HT2CR）的变构调节剂
- Patent Title: Allosteric modulators of 5-hydroxytryptamine 2C receptor (5-HT2CR)
- Patent Title (中): 5-羟色胺2C受体（5-HT2CR）的变构调节剂
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Application No.: US14363141Application Date: 2012-12-07
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Publication No.: US09533973B2Publication Date: 2017-01-03
- Inventor: Jia Zhou , Chunyong Ding , Kathryn A. Cunningham
- Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Agency: Norton Rose Fulbright US LLP
- International Application: PCT/US2012/068360 WO 20121207
- International Announcement: WO2013/086266 WO 20130613
- Main IPC: C07D211/32
- IPC: C07D211/32 ; C07D405/12 ; C07D223/16 ; C07D241/04 ; C07D211/34 ; C07D211/60 ; C07H15/14 ; C07H15/16 ; C07D309/10
Abstract:
The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases.
Public/Granted literature
- US20140336375A1 ALLOSTERIC MODULATORS OF 5-HYDROXYTRYPTAMINE 2C RECEPTOR (5-HT2CR) Public/Granted day:2014-11-13
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