Invention Grant
US09533952B2 N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists
有权
N-丙-2-炔基甲酰胺衍生物及其作为TRPA1拮抗剂的用途
- Patent Title: N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists
- Patent Title (中): N-丙-2-炔基甲酰胺衍生物及其作为TRPA1拮抗剂的用途
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Application No.: US14674940Application Date: 2013-09-30
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Publication No.: US09533952B2Publication Date: 2017-01-03
- Inventor: Riina Arvela , Terhi Heikkinen , Patrik Holm , Peteris Prusis , Mattias Roslund , Harri Salo
- Applicant: Orion Corporation
- Applicant Address: FI Espoo
- Assignee: ORION CORPORATION
- Current Assignee: ORION CORPORATION
- Current Assignee Address: FI Espoo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- International Application: PCT/FI2013/000034 WO 20130930
- International Announcement: WO2014/053694 WO 20140410
- Main IPC: C07C237/30
- IPC: C07C237/30 ; C07D317/58 ; C07D417/12 ; C07C323/63 ; C07D213/82 ; C07D209/08 ; C07D319/18 ; A61K31/166 ; C07C255/58 ; C07D333/38 ; C07C237/44 ; C07D239/42 ; C07D213/81 ; C07D215/48 ; C07D405/12 ; A61K31/277 ; A61K31/357 ; A61K31/4439 ; A61K31/444 ; A61K31/455 ; A61K31/472 ; A61K31/505 ; A61K31/5377 ; C07C255/60 ; C07D217/02 ; C07D401/12
Abstract:
Compounds of formula I, wherein A, B, X, Z and R1-R6, are as defined in the claims, exhibit TRPA 1 activity and are thus useful as TRPA1 modulators.
Public/Granted literature
- US20150376130A1 N-PROP-2-YNYL CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS Public/Granted day:2015-12-31
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