Disclosed is a device and related method for biological manipulation. With greater particularity, disclosed is a novel device and method for uniform cellular manipulation with economies of scale and operational uniformity. The device and related method utilize a cellular wounder (101) to uniformly remove portions of a cell monolayer in a multi-well plate (303) to create uniform cell samples with reduced time and expense to the user. The multi-channel mechanical wounder is a useful tool for performing cellular wounding by providing consistent and even denudation of a defined area of monolayer of cells in standard culture plates. This easy-to-assemble and user friendly device is most applicable for high throughput screening of samples such as in the manipulation of cells for cell migration or wound healing assay preparation.