Invention Grant
US09533057B2 Immunogenic HPV L2-containing VLPs and related compositions, constructs, and therapeutic methods
有权
含免疫原性HPV2V的VLP及相关组合物，构建体和治疗方法
- Patent Title: Immunogenic HPV L2-containing VLPs and related compositions, constructs, and therapeutic methods
- Patent Title (中): 含免疫原性HPV2V的VLP及相关组合物，构建体和治疗方法
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Application No.: US13577484Application Date: 2011-02-08
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Publication No.: US09533057B2Publication Date: 2017-01-03
- Inventor: Bryce Chackerian , David S. Peabody
- Applicant: Bryce Chackerian , David S. Peabody
- Applicant Address: US NM Albuquerque
- Assignee: STC.UNM
- Current Assignee: STC.UNM
- Current Assignee Address: US NM Albuquerque
- Agent Henry D. Coleman; R. Neil Sudol
- International Application: PCT/US2011/024030 WO 20110208
- International Announcement: WO2011/100234 WO 20110818
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K47/48 ; A61K39/12 ; A61K39/00
Abstract:
The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of human papillomavirus (HPV) infections and related disorders, including cervical cancer and persistent infections associated with HPV. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against HPV infection, confer immunity against HPV infection, protect against HPV infection, and reduce the likelihood of infection by HPV infection.
Public/Granted literature
- US20120308592A1 Immunogenic HPV L2-Containing VLPs and Related Compositions, Constructs, and Therapeutic Methods Public/Granted day:2012-12-06
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