Invention Grant
- Patent Title: Aqueous ophthalmic suspension of crystalline rebamipide
- Patent Title (中): 结晶瑞巴派特水性眼用悬浮液
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Application No.: US14887222Application Date: 2015-10-19
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Publication No.: US09533052B2Publication Date: 2017-01-03
- Inventor: Takakuni Matsuda , Shogo Hiraoka , Yuso Tomohira , Shinichi Ishikawa
- Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
- Current Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JP2004-330140 20041115
- Main IPC: A61K31/47
- IPC: A61K31/47 ; A61K47/38 ; A61K9/00 ; A61K9/10 ; A61K31/4704 ; A61K47/10 ; A61K47/26 ; A61K47/32

Abstract:
The invention provides an ophthalmic product containing rebamipide, which has a transparency enough to be agreeable feeling on using it and has neutral so weakly acidic pH not to injury of the keratoconjunctiva of a patient suffering from dry eye. An aqueous suspension of crystalline rebamipide which has an improved transparency is provided by adding an aqueous solution of rebamipide dissolved by a base such as sodium hydroxide or an aqueous solution of a salt of rebamipide to an aqueous acidic solution such as hydrochloric acid containing at least one of the compounds selected from water-soluble polymers and surfactants, and mixing them.
Public/Granted literature
- US20160101183A1 AQUEOUS OPHTHALMIC SUSPENSION OF CRYSTALLINE REBAMIPIDE Public/Granted day:2016-04-14
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