Invention Grant
US09532999B2 TLR4 inhibitors for the treatment of human infectious and inflammatory disorders
有权
用于治疗人类感染性和炎症性疾病的TLR4抑制剂
- Patent Title: TLR4 inhibitors for the treatment of human infectious and inflammatory disorders
- Patent Title (中): 用于治疗人类感染性和炎症性疾病的TLR4抑制剂
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Application No.: US14717349Application Date: 2015-05-20
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Publication No.: US09532999B2Publication Date: 2017-01-03
- Inventor: Peter Wipf , Matthew D. Neal , Sodhi P. Chhinder , David J. Hackam
- Applicant: University of Pittsburgh—of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Current Assignee Address: US PA Pittsburgh
- Agency: Baker Botts L.L.P.
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; A61K31/7024 ; A61K31/7008 ; A61K31/7034 ; A61K31/7028
Abstract:
The present invention relates to methods of treating infectious, inflammatory and post-traumatic disorders by administering various compounds newly discovered to have TLR4 inhibitory activity. In addition to methods of treatment, the present invention further provides for pharmaceutical compositions comprising said compounds, together with a suitable pharmaceutical carrier. Because TLR4 is the most upstream receptor in the pro-inflammatory LPS signaling cascade, treatments of the invention, which inhibit or antagonize TLR4 action, may avoid the pitfalls associated with other cytokine inhibitors that act further down the pathway and accordingly play a less specific (and perhaps non-critical) role.
Public/Granted literature
- US20150250809A1 NOVEL TLR4 INHIBITORS FOR THE TREATMENT OF HUMAN INFECTIOUS AND INFLAMMATORY DISORDERS Public/Granted day:2015-09-10
Information query
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