Invention Grant
US09532994B2 Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
有权
用于通过与骨形态发生蛋白结合的氧固醇来增强骨形成的药剂和方法
- Patent Title: Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
- Patent Title (中): 用于通过与骨形态发生蛋白结合的氧固醇来增强骨形成的药剂和方法
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Application No.: US10569994Application Date: 2004-08-30
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Publication No.: US09532994B2Publication Date: 2017-01-03
- Inventor: Farhad Parhami
- Applicant: Farhad Parhami
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- International Application: PCT/US2004/028162 WO 20040830
- International Announcement: WO2005/020928 WO 20050310
- Main IPC: A61K31/56
- IPC: A61K31/56 ; A61K31/22 ; A61K31/59 ; A61K31/66 ; A61K33/06 ; A61K38/18 ; C12N5/077
Abstract:
The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and methods to treat patients to maintain bone mass, enhance bone formation and/or bone repair. Exemplary agents include oxysterols, alone or in combination with particular oxysterols, or other agents, such as bone morphogenic proteins, known to assist in bone formation. The invention further includes medicaments including oxysterols for the treatment of bone disorders and implants to facilitate bone repair.
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