A direct current-to-direct current (DC-DC) power supply includes a voltage converter module that converts an input voltage having a first voltage level into an output voltage having a second voltage level that is less than the first voltage level. An over-voltage detection module receives the second voltage and generates an over-voltage signal indicating an over-voltage condition of the DC-DC power supply. A shutdown module receives the over-voltage signal and generates a shutdown signal in response to the over-voltage condition. An over-voltage protection module interposed between the shutdown module and the input of the voltage converter module. The over-voltage protection module is configured to selectively inhibit delivery of the input voltage to the voltage converter module in response to the shutdown signal.