Systems, devices, circuits, and methods are provided for an improved mass spectrometry detection system that comprises at least one component that operates at a high voltage. A number of high voltage filters or circuits are provided for reducing noise from high voltage power supplies that produce positive and negative voltages. In some embodiments, the filters can comprise one or more diodes. In some embodiments, the filters can comprise one or more transistors. In some embodiments, the filters can comprise one or more transistor pairs. A variety of embodiments of systems, devices, circuits, and methods in conjunction with the disclosures are provided.