Disclosed are a radio frequency locating system and method, which efficiently solve the problem of precise locating a moving target tag in a complex environment by using a method where location information is provided for a mobile tag by using low-cost fixed active RFID tags in place of a plurality of readers requiring network connection, and the location information of the mobile tag is directly transferred to a reader at the center of a locating area from a long distance by using a mobile or fixed location tag. The present invention uses a long-distance coordinator and clock information in a transmission instruction to coordinate and schedule communication time between the mobile tag and the location tag, thereby ensuring a super long battery life of the mobile tag and the location tag.