Disclosed is a method for driving a two-wheel self-balancing scooter to maintain straight drivability at occurrence of external force. The method includes a driving ready step of applying a power to the two-wheel self-balancing scooter (S10), a driving step of setting a driving speed and a forward/backward direction by leaning an occupant's body forward or backward (S20), when one wheel goes flat, a revolutions increasing step of rapidly increasing revolutions of the flat wheel (S30), a revolutions decreasing step of decreasing revolutions of a normal wheel according to the revolutions of the flat wheel (S40), a revolutions synchronizing step of equally setting the revolutions of the flat wheel and the normal wheel (S50), and a synchronization repeating step of repeating the revolutions synchronizing step (S60).